Mixed-lineage kinase control of JNK and p38 MAPK pathways

Kathleen A Gallo; Gary L Johnson

doi:10.1038/nrm906

Mixed-lineage kinase control of JNK and p38 MAPK pathways

Nat Rev Mol Cell Biol. 2002 Sep;3(9):663-72. doi: 10.1038/nrm906.

Authors

Kathleen A Gallo¹, Gary L Johnson

Affiliation

¹ Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA. gallok@msu.edu

PMID: 12209126
DOI: 10.1038/nrm906

Abstract

Mixed-lineage kinases (MLKs) are serine/threonine protein kinases that regulate signalling by the c-Jun amino-terminal kinase (JNK) and p38 mitogen-activated-protein kinase (MAPK) pathways. MLKs are represented in the genomes of both Caenorhabditis elegans and Drosophila melanogaster. The Drosophila MLK Slipper regulates JNK to control dorsal closure during embryonic morphogenesis. In mammalian cells, MLKs are implicated in the control of apoptosis and are potential drug targets for many neurodegenerative diseases.

Publication types

Review

MeSH terms

Animals
Dimerization
Humans
JNK Mitogen-Activated Protein Kinases
MAP Kinase Signaling System*
Mitogen-Activated Protein Kinases / metabolism*
Phosphorylation
Protein Serine-Threonine Kinases / chemistry
Protein Serine-Threonine Kinases / classification
Protein Serine-Threonine Kinases / metabolism*
p38 Mitogen-Activated Protein Kinases
rho GTP-Binding Proteins / metabolism
src Homology Domains

Substances

Protein Serine-Threonine Kinases
JNK Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
rho GTP-Binding Proteins