Abstract
A 45 year old female patient presented with the cutaneous manifestations of malignant atrophic papulosis (Köhlmeier-Degos disease) for two years. The typical papules with central porcelain-white atrophy correspond histologically to wedge-shaped necrosis of the connective tissue due to thrombotic occlusion of small vessels in the corium. The pathogenesis of malignant atrophic papulosis and effective treatment modalities are unknown. A slow virus infection has been suggested by some authors. Therefore, we attempted an immune therapy with interferon alpha-2a over a period of 11 months, but failed to cause a significant effect on the appearance and progression of the skin lesions. Furthermore, we could not confirm the effectiveness of a recently reported treatment modality with pentoxifylline and aspirin administered to our patient over a period of 5 months.
MeSH terms
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Aspirin / administration & dosage*
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Atrophy
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Connective Tissue / blood supply
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Connective Tissue / pathology*
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Diagnosis, Differential
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Disease Progression
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Drug Therapy, Combination
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Female
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Humans
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Interferon alpha-2
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Interferon-alpha / administration & dosage*
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Middle Aged
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Pentoxifylline / administration & dosage*
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Recombinant Proteins
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Skin / blood supply
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Skin / pathology
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Skin Diseases, Papulosquamous / drug therapy*
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Skin Diseases, Papulosquamous / immunology
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Skin Diseases, Papulosquamous / pathology
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Skin Diseases, Vascular / drug therapy*
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Skin Diseases, Vascular / immunology
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Skin Diseases, Vascular / pathology
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Slow Virus Diseases / drug therapy*
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Slow Virus Diseases / immunology
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Slow Virus Diseases / pathology
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Thrombosis / drug therapy*
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Thrombosis / immunology
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Thrombosis / pathology
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Treatment Failure
Substances
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Interferon alpha-2
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Interferon-alpha
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Recombinant Proteins
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Aspirin
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Pentoxifylline