Objective: To investigate the changes of plasma tissue factor(TF) and tissue factor pathway inhibitor(TFPI) activities in the patients with acute leukemia.
Methods: TF and TFPI activities were measured by using chromogenic assays.
Results: Plasma TF activity in the patients with acute leukemia was higher and TFPI activity was lower than those in normal(P < 0.01). In 7 patients who underwent the first chemotherapy, the plasma TF activity was decreased after chemotherapy(P < 0.01), while TFPI activity increased(P < 0.05).
Conclusion: The unbalance between plasma TF and TFPI activities contributes to the coagulant disorders in acute leukemia.