Substrate distortion by a beta-mannanase: snapshots of the Michaelis and covalent-intermediate complexes suggest a B(2,5) conformation for the transition state

Angew Chem Int Ed Engl. 2002 Aug 2;41(15):2824-7. doi: 10.1002/1521-3773(20020802)41:15<2824::AID-ANIE2824>3.0.CO;2-G.

Authors

Valérie M-A Ducros¹, David L Zechel, Garib N Murshudov, Harry J Gilbert, Lóránd Szabó, Dominik Stoll, Stephen G Withers, Gideon J Davies

Affiliation

¹ Department of Chemistry, Structural Biology Laboratory, The University of York, Heslington, York, YO10 5DD, UK.

PMID: 12203498
DOI: 10.1002/1521-3773(20020802)41:15<2824::AID-ANIE2824>3.0.CO;2-G

No abstract available

MeSH terms

Catalysis
Glycosylation
Hexoses / chemistry*
Hexoses / metabolism
Mannosidases / chemistry*
Mannosidases / metabolism
Models, Molecular
Molecular Conformation
beta-Mannosidase

Substances

Hexoses
Mannosidases
beta-Mannosidase