The Rayleigh-Taylor instability in its highly nonlinear, turbulent stage causes atomic-scale mixing of the shell material with the fuel in the compressed core of inertial-confinement fusion targets. The density of shell material mixed into the outer core of direct-drive plastic-shell spherical-target implosions on the 60-beam, OMEGA laser system is estimated to be 3.4(+/-1.2) g/cm(3) from time-resolved x-ray spectroscopy, charged-particle spectroscopy, and core x-ray images. The estimated fuel density, 3.6(+/-1) g/cm(3), accounts for only approximately 50% of the neutron-burn-averaged electron density, n(e)=2.2(+/-0.4)x10(24) cm(-3).