Simultaneous expression of different variant-specific surface proteins in single Giardia lamblia trophozoites during encystation

Infect Immun. 2002 Sep;70(9):5265-8. doi: 10.1128/IAI.70.9.5265-5268.2002.

Abstract

A novel variant-specific surface protein (VSP) from Giardia was identified using the monoclonal antibody 9B10, raised against purified cyst walls. VSP9B10B is preferentially induced during encystation and expressed simultaneously with other VSPs on the surface of encysting trophozoites. These results support the hypothesis that encystation and antigenic variation are processes that are mechanistically related.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Antibodies, Protozoan
  • Antigenic Variation
  • Antigens, Protozoan / genetics*
  • Antigens, Surface / genetics*
  • Base Sequence
  • DNA, Protozoan / genetics
  • Gene Expression
  • Genes, Protozoan
  • Giardia lamblia / genetics*
  • Giardia lamblia / immunology*
  • Giardia lamblia / pathogenicity
  • Humans
  • Molecular Sequence Data
  • Protozoan Proteins*
  • Sequence Homology, Amino Acid

Substances

  • Antibodies, Monoclonal
  • Antibodies, Protozoan
  • Antigens, Protozoan
  • Antigens, Surface
  • DNA, Protozoan
  • Protozoan Proteins
  • variant surface protein H7, Giardia lamblia