Abstract
A series of potential bioactive compounds, 1-glucopyranosyl- 1,2,3-triazole-4,5-dimethylcarboxylate, 1-glucopyranosyl-1,2,3-triazole-4,5-N-dicarboxamide,-dialkyl-dicarboxamide-N-nucleosides and 6-amino-4H-1-(beta-D-glucopyranosyl)-8-hydroxy-1,2.3-triazolo[4,5-e][1,3]-diazepin-4-one, were synthesized. Primary activity screening of the novel nucleosides showed poor or no anticancer activity against breast, lung and CNS tumors.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Cell Division / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Models, Chemical
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Neoplasms / drug therapy*
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Nucleosides / chemical synthesis*
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Nucleosides / pharmacology
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Triazoles / chemical synthesis*
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Triazoles / pharmacology
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Nucleosides
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Triazoles