Abstract
Two recent papers in Cell and Developmental Cell provide evidence that VEGF directs arterial differentiation. Evidence that sensory nerves direct arteriogenesis and that the membrane-spanning Notch signaling system is downstream of VEGF emphasize the paracrine regulation of vessel formation.
MeSH terms
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Animals
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Arteries / embryology*
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Arteries / innervation*
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Arteries / metabolism
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Cell Communication / physiology*
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Cell Differentiation / physiology
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Embryonic Induction / physiology*
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Endothelial Growth Factors / genetics
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Endothelial Growth Factors / metabolism*
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Gene Expression Regulation, Developmental / physiology
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Humans
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Lymphokines / genetics
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Lymphokines / metabolism*
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Neovascularization, Physiologic / genetics*
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Paracrine Communication / genetics
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Peripheral Nerves / embryology*
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Peripheral Nerves / metabolism
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Receptors, Notch
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors
Substances
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Endothelial Growth Factors
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Lymphokines
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Membrane Proteins
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Receptors, Notch
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors