Won't you be my neighbor? Local induction of arteriogenesis

Cell. 2002 Aug 9;110(3):289-92. doi: 10.1016/s0092-8674(02)00869-3.

Abstract

Two recent papers in Cell and Developmental Cell provide evidence that VEGF directs arterial differentiation. Evidence that sensory nerves direct arteriogenesis and that the membrane-spanning Notch signaling system is downstream of VEGF emphasize the paracrine regulation of vessel formation.

Publication types

  • Review

MeSH terms

  • Animals
  • Arteries / embryology*
  • Arteries / innervation*
  • Arteries / metabolism
  • Cell Communication / physiology*
  • Cell Differentiation / physiology
  • Embryonic Induction / physiology*
  • Endothelial Growth Factors / genetics
  • Endothelial Growth Factors / metabolism*
  • Gene Expression Regulation, Developmental / physiology
  • Humans
  • Lymphokines / genetics
  • Lymphokines / metabolism*
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Neovascularization, Physiologic / genetics*
  • Paracrine Communication / genetics
  • Peripheral Nerves / embryology*
  • Peripheral Nerves / metabolism
  • Receptors, Notch
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Endothelial Growth Factors
  • Lymphokines
  • Membrane Proteins
  • Receptors, Notch
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors