Abstract
A model of the simplest epigene was constructed to have two alternative states, which proved to be stable and transmittable through Escherichia coli cell generations. A switch from one to another state was induced by thermal and chemical external signals. The results gave further insight into the dynamic mechanism of preservation, coding, and transmission of the genetic information.
MeSH terms
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Bacterial Proteins / genetics*
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Bacterial Proteins / metabolism
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DNA-Binding Proteins*
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Escherichia coli / drug effects
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Escherichia coli / genetics*
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Escherichia coli / metabolism
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Escherichia coli Proteins*
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Gene Expression Regulation, Bacterial / drug effects
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Genetic Engineering / methods*
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Isopropyl Thiogalactoside / pharmacology
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Lac Repressors
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Plasmids / genetics
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Promoter Regions, Genetic
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Repressor Proteins / genetics*
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Repressor Proteins / metabolism
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Temperature
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Viral Proteins
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Viral Regulatory and Accessory Proteins
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beta-Galactosidase / genetics
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beta-Galactosidase / metabolism
Substances
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Bacterial Proteins
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DNA-Binding Proteins
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Escherichia coli Proteins
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Lac Repressors
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LacI protein, E coli
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Repressor Proteins
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Viral Proteins
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Viral Regulatory and Accessory Proteins
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phage repressor proteins
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Isopropyl Thiogalactoside
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beta-Galactosidase