Abstract
A series of potential topoisomerase II-mediated anticancer 9-anilinoacridine derivatives, which are designed to avoid bio-oxidation and possessed long duration of drug action, is reviewed. Among these agents, 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA) derivatives and their alkylcarbamates have been investigated and developed for potential clinical application.
MeSH terms
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Acridines / chemistry*
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Acridines / metabolism
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Acridines / pharmacology*
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Aniline Compounds / chemistry*
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Aniline Compounds / metabolism
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Aniline Compounds / pharmacology*
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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DNA / metabolism
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Drug Design
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Humans
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Oxidation-Reduction
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Structure-Activity Relationship
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Topoisomerase II Inhibitors*
Substances
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3-(9-acridinylamino)-5-hydroxymethylaniline
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Acridines
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Aniline Compounds
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Antineoplastic Agents
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Topoisomerase II Inhibitors
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DNA