Abstract
Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4'-O-methylellagic acid 3-(2",3"-di-O-acetyl)-alpha-L-rhamnoside (1) and 4,4'-O-dimethylellagic acid 3-(2",3"-di-O-acetyl)-alpha-L-rhamnoside (2). These compounds were evaluated against a panel of human tumor cell lines.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Cucurbitacins
-
Ellagic Acid / analogs & derivatives*
-
Ellagic Acid / isolation & purification*
-
Ellagic Acid / pharmacology
-
Humans
-
Magnetic Resonance Spectroscopy
-
Magnoliopsida / chemistry*
-
Molecular Structure
-
Plant Bark / chemistry
-
Triterpenes / chemistry
-
Triterpenes / isolation & purification*
-
Triterpenes / pharmacology*
-
Tumor Cells, Cultured
Substances
-
Antineoplastic Agents, Phytogenic
-
Triterpenes
-
Ellagic Acid
-
cucurbitacin F
-
cucurbitacin D
-
Cucurbitacins