Synthesis, characterization of novel coupling products and 4-arylhydrazono-2-pyrazoline-5-ones as potential antimycobacterial agents

S Güniz Küçükgüzel; Sevim Rollas

doi:10.1016/s0014-827x(02)01253-3

Synthesis, characterization of novel coupling products and 4-arylhydrazono-2-pyrazoline-5-ones as potential antimycobacterial agents

Farmaco. 2002 Jul;57(7):583-7. doi: 10.1016/s0014-827x(02)01253-3.

Authors

S Güniz Küçükgüzel¹, Sevim Rollas

Affiliation

¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Haydarpaşa, Istanbul, Turkey.

PMID: 12164219
DOI: 10.1016/s0014-827x(02)01253-3

Abstract

Novel coupling products 7a-d and 4-arylhydrazono-2-pyrazoline-5-ones 8a-e were synthesized and evaluated for antimycobacterial activity against Mycobacterium tuberculosis H37Rv and Mycobacterium avium. Compound 7b was found to be the most potent derivatives of the 7a-d series by an MIC value of 6.25 microg/ml.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / chemical synthesis*
Antitubercular Agents / chemistry
Antitubercular Agents / pharmacology
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Mycobacterium avium / drug effects*
Mycobacterium tuberculosis / drug effects*
Pyrazoles / chemical synthesis*
Pyrazoles / chemistry
Pyrazoles / pharmacology

Substances

Antitubercular Agents
Pyrazoles