CHEMICAL SUBMISSION: Certain forms of sexual abuse have recourse to molecules in order to obtain the victim's submission. These fast-acting, muscle-relaxing and sedative molecules, provoke anterograde amnesia that makes subsequent legal enquiries difficult. These products can be combined with alcohol or other addictive substances, therefore facilitating their administration, without the victim knowing, and enhancing their effects. THE MOLECULES USED: Among these molecules, hydroxybutyrate and its derivatives as well as benzodiazepines, with flunitrazepam, are frequently mentioned and detected. However, many other sedative molecules can be used to obtain chemical submission. MANAGEMENT OF THE VICTIMS: Knowledge of the facts and concomitant symptoms facilitates the medical and medico-legal management of the victims, generally encountered in hospital emergency wards. The quality and quantity of toxicological samples permit the use of efficient and validated techniques in organizing medico-legal enquiries.