Palladium(II)-mediated cascade carbonylative annulation of o-alkynyl-phenols on silyl linker-based macrobeads: a combinatorial synthesis of a 2,3-disubstituted benzo[b]furan library

Org Lett. 2002 Jul 25;4(15):2607-9. doi: 10.1021/ol020111y.

Abstract

[reaction: see text] A palladium(II)-mediated cascade carbonylative annulation of o-alkynylphenols was achieved successfully on silyl linker-based macrobeads, which led to an efficient combinatorial synthesis of a 2,3-disubstituted benzo[b]furan library.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkynes / chemistry
  • Benzofurans / chemical synthesis*
  • Biological Factors / chemical synthesis
  • Carbon Monoxide / chemistry
  • Catalysis
  • Combinatorial Chemistry Techniques*
  • Palladium / chemistry
  • Phenols / chemistry
  • Resins, Synthetic

Substances

  • Alkynes
  • Benzofurans
  • Biological Factors
  • Phenols
  • Resins, Synthetic
  • Palladium
  • Carbon Monoxide
  • benzofuran