Incidence, epidemiology, and characteristics of quinolone-nonsusceptible Streptococcus pneumoniae in Croatia

Antimicrob Agents Chemother. 2002 Aug;46(8):2671-5. doi: 10.1128/AAC.46.8.2671-2675.2002.

Abstract

Among 585 Streptococcus pneumoniae strains isolated in 22 Croatian hospitals 21 strains (3.6%) were quinolone nonsusceptible. MICs of all quinolones were high for seven strains tested with the same serotype (23F) and mutations in gyrA, parC, and parE. The remaining 14 strains were more heterogeneous and had mutations only in parC and/or parE, and the MICs of quinolones were lower for these strains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Quinolones
  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology*
  • Child
  • Community-Acquired Infections / epidemiology
  • Community-Acquired Infections / microbiology
  • Croatia / epidemiology
  • Cross Infection / epidemiology
  • Cross Infection / microbiology
  • Drug Resistance, Microbial
  • Female
  • Geography
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mutation
  • Penicillin Resistance
  • Pneumococcal Infections / epidemiology*
  • Pneumococcal Infections / microbiology*
  • Sex Factors
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / genetics

Substances

  • 4-Quinolones
  • Anti-Bacterial Agents