Abstract
A series of 2-(3,4,5-trimethoxyphenyl)-3-arylcyclopent-2-ene-1-ones (8a-8e) and their related analogues, including pentenone 9a, pentenol 10a, pentene 12a, and furane 15, were synthesized and evaluated for cytotoxicity against murine and human tumor cell lines. Compounds 8a-c, 8e and 9a showed strong cytotoxicity with IC(50) values in the range of 8-34ng/mL. Compound 8e exhibited significant anti-tumor activity in BDF1 mice bearing Lewis lung carcinoma cells with an inhibition ratio of 59%.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Bibenzyls / chemical synthesis*
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Bibenzyls / pharmacology*
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Carcinoma, Lewis Lung / drug therapy
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Cyclopentanes / chemistry*
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Cyclopentanes / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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Mice
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Stereoisomerism
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Stilbenes*
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Bibenzyls
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Cyclopentanes
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Stilbenes
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combretastatin
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cyclopentenone