Abstract
A role for chemokines as mediators of Th1 cell recruitment to the central nervous system (CNS) is probable in MS. Therefore we studied expression of Th1-related CCR5 and CXCR3 chemokine receptors in patients with MS and controls. Patients with untreated MS had elevated percentages of CCR5 and CXCR3 expressing T cells vs. healthy controls (HC) in blood, and vs. other non-inflammatory neurological diseases (OND) patients in CSF. Such elevation was not found in MS patients examined during ongoing treatment with IFN-beta. Patients with optic neuritis (ON), a common first manifestation of MS, had elevated percentages of CXCR3 expressing T cells in blood compared with HC, and of CCR5 expressing T cells in CSF compared with OND patients. High chemokine receptor expression may be one prerequisite for Th1 cells to migrate to the CNS. Inhibition of chemokine receptor expression may constitute a potentially important therapeutic effect of IFN-beta.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Cell Count
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Chemokine CCL5 / blood
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Chemokine CCL5 / cerebrospinal fluid
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Chemokine CXCL10
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Chemokines, CXC / blood
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Chemokines, CXC / cerebrospinal fluid
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Chemotaxis, Leukocyte / immunology*
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Female
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Humans
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Interferon-beta / pharmacology
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Interferon-beta / therapeutic use
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Male
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Middle Aged
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Multiple Sclerosis / blood*
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Multiple Sclerosis / cerebrospinal fluid*
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Multiple Sclerosis / immunology
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Multiple Sclerosis, Chronic Progressive / blood
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Multiple Sclerosis, Chronic Progressive / cerebrospinal fluid
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Multiple Sclerosis, Chronic Progressive / immunology
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Multiple Sclerosis, Relapsing-Remitting / blood
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Multiple Sclerosis, Relapsing-Remitting / cerebrospinal fluid
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Multiple Sclerosis, Relapsing-Remitting / immunology
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Optic Neuritis / blood*
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Optic Neuritis / cerebrospinal fluid*
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Optic Neuritis / immunology
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Receptors, CCR5 / blood*
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Receptors, CCR5 / immunology
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Receptors, CXCR3
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Receptors, Chemokine / blood*
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Receptors, Chemokine / immunology
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Th1 Cells / immunology*
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Up-Regulation / immunology*
Substances
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CXCR3 protein, human
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Chemokine CCL5
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Chemokine CXCL10
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Chemokines, CXC
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Receptors, CCR5
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Receptors, CXCR3
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Receptors, Chemokine
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Interferon-beta