Abstract
The in vitro antitumor activities of 2,6-di-[2-(heteroaryl)vinyl]pyridines versus the standard National Cancer Institute 60 cell lines panel and of 2,6-di-[2-(heteroaryl)vinyl] pyridinium cations versus MCF7 (human mammary carcinoma) and LNCap (prostate carcinoma) cell lines are reported. Antiproliferative effects in both series are particularly evident for MCF7 mammary adenocarcinoma cells. Multivariate analysis of DNA microarray data for responsive tumor cell lines suggest a mechanistic pathway involving polyamine biosynthesis and prolactin signal transduction.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / pharmacology*
-
Female
-
Gene Expression Profiling
-
Humans
-
Male
-
Multivariate Analysis
-
Oligonucleotide Array Sequence Analysis
-
Polyamines / metabolism
-
Prolactin / metabolism
-
Pyridines / chemical synthesis
-
Pyridines / pharmacology*
-
Pyridinium Compounds / chemical synthesis
-
Pyridinium Compounds / pharmacology*
-
Signal Transduction
-
Structure-Activity Relationship
-
Tumor Cells, Cultured
Substances
-
Antineoplastic Agents
-
Polyamines
-
Pyridines
-
Pyridinium Compounds
-
Prolactin