Abstract
Two new sphingosine 4-sulfates (1 and 2) have been isolated from the sponge Spirastrella abata as cytotoxic constituents. The gross structures of 1 and 2 were determined by spectroscopic analysis, and their stereochemistry was established by chemical conversion. The compounds exhibited significant cytotoxicity against a small panel of five human tumor cell lines.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / isolation & purification*
-
Antineoplastic Agents / pharmacology
-
Chromatography, High Pressure Liquid
-
Drug Screening Assays, Antitumor
-
Female
-
Humans
-
Korea
-
Lung Neoplasms
-
Molecular Structure
-
Nervous System Neoplasms
-
Nuclear Magnetic Resonance, Biomolecular
-
Ovarian Neoplasms
-
Porifera / chemistry*
-
Sphingosine* / analogs & derivatives
-
Sphingosine* / chemistry
-
Sphingosine* / isolation & purification
-
Sphingosine* / pharmacology
-
Stereoisomerism
-
Sulfates / chemistry
-
Sulfates / isolation & purification*
-
Sulfates / pharmacology
-
Tumor Cells, Cultured / drug effects
Substances
-
Antineoplastic Agents
-
Sulfates
-
Sphingosine