Cytotoxic sphingosine 4-sulfates from the sponge Spirastrella abata

J Nat Prod. 2002 Jun;65(6):944-5. doi: 10.1021/np010312v.

Abstract

Two new sphingosine 4-sulfates (1 and 2) have been isolated from the sponge Spirastrella abata as cytotoxic constituents. The gross structures of 1 and 2 were determined by spectroscopic analysis, and their stereochemistry was established by chemical conversion. The compounds exhibited significant cytotoxicity against a small panel of five human tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Chromatography, High Pressure Liquid
  • Drug Screening Assays, Antitumor
  • Female
  • Humans
  • Korea
  • Lung Neoplasms
  • Molecular Structure
  • Nervous System Neoplasms
  • Nuclear Magnetic Resonance, Biomolecular
  • Ovarian Neoplasms
  • Porifera / chemistry*
  • Sphingosine* / analogs & derivatives
  • Sphingosine* / chemistry
  • Sphingosine* / isolation & purification
  • Sphingosine* / pharmacology
  • Stereoisomerism
  • Sulfates / chemistry
  • Sulfates / isolation & purification*
  • Sulfates / pharmacology
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents
  • Sulfates
  • Sphingosine