Decipinin A and decipienolides A and B: new bioactive metabolites from the coprophilous fungus Podospora decipiens

J Nat Prod. 2002 Jun;65(6):916-9. doi: 10.1021/np010575p.

Abstract

Decipinin A (1), a new compound with antifungal and antibacterial activity, has been isolated from liquid cultures of the coprophilous fungus Podospora decipiens (JS 270). Two new tetracyclic sesquiterpene lactones, decipienolides A (2) and B (3), were also obtained from this isolate as an inseparable mixture of epimers that showed antibacterial activity. The structures of 1-3 were elucidated by analysis of 1D and 2D NMR data, aided by chemical shift comparisons to related compounds.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification*
  • Anti-Infective Agents / pharmacology
  • Ascomycota / chemistry*
  • Ascomycota / drug effects
  • Australia
  • Bacillus subtilis / drug effects
  • Benzopyrans / chemistry
  • Benzopyrans / isolation & purification*
  • Benzopyrans / pharmacology
  • Candida albicans / drug effects
  • Chromatography, High Pressure Liquid
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Stereoisomerism

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Benzopyrans
  • Sesquiterpenes
  • decipienolide A
  • decipienolide B
  • decipinin A