Linkage of Patr-AL to Patr-A and- B in the major histocompatibility complex of the common chimpanzee (Pan troglodytes)

Ron Geller; Erin J Adams; Lisbeth A Guethlein; Ann-Margaret Little; J Alejandro Madrigal; Peter Parham

doi:10.1007/s00251-002-0452-x

Linkage of Patr-AL to Patr-A and- B in the major histocompatibility complex of the common chimpanzee (Pan troglodytes)

Immunogenetics. 2002 Jun;54(3):212-5. doi: 10.1007/s00251-002-0452-x. Epub 2002 Apr 11.

Authors

Ron Geller¹, Erin J Adams, Lisbeth A Guethlein, Ann-Margaret Little, J Alejandro Madrigal, Peter Parham

Affiliation

¹ Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305-5126, USA.

PMID: 12073151
DOI: 10.1007/s00251-002-0452-x

Abstract

Patr-AL is a recently described gene found only in the common chimpanzee, but closely related in structure to the highly polymorphic Patr-A and HLA-A genes of the chimpanzee and human MHCs, respectively. Unlike Patr-A and HLA-A, the Patr-AL gene has little polymorphism and is not fixed in the chimpanzee genome. To determine whether Patr-AL is located in the MHC or elsewhere, we compared segregation of the Patr-AL gene with segregation of Patr-A and - B alleles in chimpanzee families. The results demonstrate that Patr-AL is an MHC class I gene present on different MHC haplotypes as defined by their combination of Patr-A and B alleles.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Female
Gene Frequency
Genes, MHC Class I*
Genetic Linkage*
Haplotypes
Histocompatibility Antigens Class I / genetics*
Male
Pan troglodytes / genetics*
Pedigree
Polymorphism, Single-Stranded Conformational

Substances

Histocompatibility Antigens Class I

Grants and funding

AI31168/AI/NIAID NIH HHS/United States