Abstract
We describe the clinicopathologic and immunohistochemical features and microsatellite instability analysis of a rare case of endometrial endometrioid adenocarcinoma presenting as a metastasis to the ischium in a 39-year-old premenopausal woman. The patient was treated with a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic and para-aortic lymphadenectomy. One month later, she underwent an ischial resection followed by radiotherapy. After a follow-up of 3 years, the patient shows no evidence of disease.
MeSH terms
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Adaptor Proteins, Signal Transducing
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Adult
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Bone Neoplasms / secondary*
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Carcinoma, Endometrioid / genetics
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Carcinoma, Endometrioid / pathology*
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Carrier Proteins
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DNA-Binding Proteins*
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Endometrial Neoplasms / genetics
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Endometrial Neoplasms / pathology*
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Female
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Humans
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Ischium / pathology*
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Microsatellite Repeats / genetics
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MutL Protein Homolog 1
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MutS Homolog 2 Protein
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Neoplasm Proteins / biosynthesis
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Nuclear Proteins
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Premenopause
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Proto-Oncogene Proteins / biosynthesis
Substances
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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DNA-Binding Proteins
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MLH1 protein, human
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Neoplasm Proteins
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Nuclear Proteins
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Proto-Oncogene Proteins
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MSH2 protein, human
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MutL Protein Homolog 1
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MutS Homolog 2 Protein