At the present the age-specific particularities of many organs and systems used in diagnostics are determined. The function--morphological state of the biliary system in different age groups is poorly studied. The age-specific particularities of biligenesis in norm (control group--90 persons) and in pathology were studied by the following traditional methods: multifractional chromatic duodenal catheterization, dynamic scintigraphy of gallbladder, dynamic ultrasonic cholecystography. There were 167 patients with gastroduodenal diseases (chronic gastritis, gastric, duodenal and intestinal ulcers) and 115 patients with calculous cholecystites and chronic hepatites. The gastroduodenal affections reinforced the appearnce and the course of typical age alterations of biliary system. Patients sufferin from hepatobiliary pathology over 5 years biliation ability has remained in normal values.