Optical resolution of 5-alkyl-delta-valerolactones and synthesis of optically active 5-fluoroalkanols

Asep Riswoko; Yoshio Aoki; Takuji Hirose; Hiroyuki Nohira

doi:10.1080/10242430210707

Optical resolution of 5-alkyl-delta-valerolactones and synthesis of optically active 5-fluoroalkanols

Enantiomer. 2002 Jan-Feb;7(1):33-9. doi: 10.1080/10242430210707.

Authors

Asep Riswoko¹, Yoshio Aoki, Takuji Hirose, Hiroyuki Nohira

Affiliation

¹ Department of Applied Chemistry, Faculty of Engineering, Saitama University, Urawa, Japan. asep@apc.saitama-u.ac.jp

PMID: 12043944
DOI: 10.1080/10242430210707

Abstract

Optical resolutions of 5-alkyl-delta-valerolactones were carried out by derivatization to the diastereomeric amides, in which (R)-(+)-1-(1-naphthyl)ethylamine or (S)-(-)-1-phenylethylamine were used as resolving agents. Optically active 5-fluoroalkanols, useful intermediates for fluorinated ferroelectric liquid crystals, were derived from the resolved lactones in four steps without racemization.