5-Bromo-2'-deoxyuridine efficiently suppresses division potential of the yeast Saccharomyces cerevisiae

Michihiko Fujii; Hisasi Ito; Tsutomu Hasegawa; Toshikazu Suzuki; Noritaka Adachi; Dai Ayusawa

doi:10.1271/bbb.66.906

5-Bromo-2'-deoxyuridine efficiently suppresses division potential of the yeast Saccharomyces cerevisiae

Biosci Biotechnol Biochem. 2002 Apr;66(4):906-9. doi: 10.1271/bbb.66.906.

Authors

Michihiko Fujii¹, Hisasi Ito, Tsutomu Hasegawa, Toshikazu Suzuki, Noritaka Adachi, Dai Ayusawa

Affiliation

¹ Division of Biochemistry, Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City University, Yokohama, Japan.

PMID: 12036074
DOI: 10.1271/bbb.66.906

Abstract

We established a thymidine-auxotrophic strain of the yeast Saccharomyces cerevisiae to examine biological effects of thymidine analogues. 5-Bromo-2'-deoxyuridine efficiently suppressed the division potential of yeast showing morphology similar to senescent cells.

MeSH terms

Bromodeoxyuridine / pharmacology*
Cell Division / drug effects
Kinetics
Saccharomyces cerevisiae / cytology
Saccharomyces cerevisiae / drug effects
Saccharomyces cerevisiae / growth & development*
Thymidine / metabolism
Time Factors

Substances

Bromodeoxyuridine
Thymidine