Synthesis and fasciolicidal activity of 5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole

Chem Pharm Bull (Tokyo). 2002 May;50(5):649-52. doi: 10.1248/cpb.50.649.

Abstract

The synthesis and fasciolicidal activity of 5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole (6) is described. Compound 6 showed 100% activity in vitro at 146.70 and 29.34 microM concentrations. It also completely removed 3-d and 10-week-old Fasciola hepatica in sheep at a dose of 15 mg/kg.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthelmintics / chemical synthesis*
  • Benzimidazoles / pharmacology
  • Crystallization
  • Fasciola hepatica / drug effects*
  • Fascioliasis / drug therapy
  • Fascioliasis / parasitology
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology*
  • Indicators and Reagents
  • Naphthalenes / chemical synthesis*
  • Naphthalenes / pharmacology*
  • Sheep
  • Structure-Activity Relationship
  • Triclabendazole

Substances

  • 5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole
  • Anthelmintics
  • Benzimidazoles
  • Imidazoles
  • Indicators and Reagents
  • Naphthalenes
  • Triclabendazole