Abstract
PksA catalyzes the formation of the polyketide backbone necessary for aflatoxin biosynthesis. Based on reporter assays and sequence comparisons of the nor1-pksA intergenic region in different aflatoxin-producing Aspergillus species, cis-acting elements for the aflatoxin pathway-specific regulatory protein, AflR, and the global-acting regulatory proteins BrlA and PacC are involved in pksA promoter activity.
MeSH terms
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Aflatoxins / biosynthesis*
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Aspergillus / enzymology
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Aspergillus / genetics*
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Aspergillus / metabolism
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Base Sequence
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Binding Sites
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Fungal Proteins / metabolism
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Molecular Sequence Data
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Multienzyme Complexes / genetics*
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Multienzyme Complexes / metabolism
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Nuclear Proteins / genetics
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Promoter Regions, Genetic*
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Transcription Factors / metabolism
Substances
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AFLR protein, Aspergillus
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Aflatoxins
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BRLA protein, Emericella nidulans
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DNA-Binding Proteins
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Fungal Proteins
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Multienzyme Complexes
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Nuclear Proteins
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PacC protein, Aspergillus
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Transcription Factors