Promoter elements in the aflatoxin pathway polyketide synthase gene

Biochim Biophys Acta. 2002 Jun 7;1576(1-2):171-5. doi: 10.1016/s0167-4781(02)00282-8.

Abstract

PksA catalyzes the formation of the polyketide backbone necessary for aflatoxin biosynthesis. Based on reporter assays and sequence comparisons of the nor1-pksA intergenic region in different aflatoxin-producing Aspergillus species, cis-acting elements for the aflatoxin pathway-specific regulatory protein, AflR, and the global-acting regulatory proteins BrlA and PacC are involved in pksA promoter activity.

Publication types

  • Comparative Study

MeSH terms

  • Aflatoxins / biosynthesis*
  • Aspergillus / enzymology
  • Aspergillus / genetics*
  • Aspergillus / metabolism
  • Base Sequence
  • Binding Sites
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Fungal Proteins / metabolism
  • Molecular Sequence Data
  • Multienzyme Complexes / genetics*
  • Multienzyme Complexes / metabolism
  • Nuclear Proteins / genetics
  • Promoter Regions, Genetic*
  • Transcription Factors / metabolism

Substances

  • AFLR protein, Aspergillus
  • Aflatoxins
  • BRLA protein, Emericella nidulans
  • DNA-Binding Proteins
  • Fungal Proteins
  • Multienzyme Complexes
  • Nuclear Proteins
  • PacC protein, Aspergillus
  • Transcription Factors