Design and synthesis of some new pyranoxanthenone aminoderivatives with cytotoxic activity

Bioorg Med Chem Lett. 2002 Jun 3;12(11):1443-6. doi: 10.1016/s0960-894x(02)00218-4.

Abstract

The synthesis, DNA binding and in vitro cytotoxicity of a series of novel pyranoxanthones, analogues of the acridone alcaloid acronycine, are described. The new compounds proved to bind weakly to DNA. On the contrary, they exhibited interesting cytotoxic activity against murine leukemia L1210 cell line, as well as against some human solid tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acridines / chemical synthesis*
  • Acridines / chemistry
  • Acridines / pharmacology
  • Acronine / analogs & derivatives*
  • Acronine / chemical synthesis
  • Acronine / pharmacology
  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Drug Design
  • Flow Cytometry
  • Fluorescence
  • HT29 Cells / drug effects
  • Humans
  • Inhibitory Concentration 50
  • Leukemia L1210 / drug therapy
  • Lung Neoplasms / drug therapy
  • Mice
  • Structure-Activity Relationship
  • Tumor Cells, Cultured / drug effects
  • Xanthenes / chemical synthesis
  • Xanthenes / chemistry
  • Xanthenes / pharmacology

Substances

  • Acridines
  • Antineoplastic Agents
  • Xanthenes
  • Acronine