Design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2- dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates

Org Lett. 2002 May 30;4(11):1851-4. doi: 10.1021/ol020047k.

Abstract

[carbohydrate structure: see text] The design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates (13, 17) as DNA minor groove binding agents are described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylene / analogs & derivatives*
  • Acetylene / chemistry
  • Aldehydes / chemistry
  • Animals
  • Antineoplastic Agents, Alkylating / chemical synthesis*
  • Benzaldehydes / chemistry
  • Drug Design
  • Drug Screening Assays, Antitumor
  • Humans
  • Indicators and Reagents
  • Indoles / chemistry*
  • Kinetics
  • Mice
  • Pyrroles / chemistry*
  • Tumor Cells, Cultured

Substances

  • Aldehydes
  • Antineoplastic Agents, Alkylating
  • Benzaldehydes
  • Indicators and Reagents
  • Indoles
  • Pyrroles
  • bis-1-chloromethyl-5-hydroxy-1,2- dihydro-3H-benz(e)indole(seco-CBI)-pyrrole polyamide
  • phenylacetylene
  • Acetylene