Abstract
[carbohydrate structure: see text] The design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates (13, 17) as DNA minor groove binding agents are described.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylene / analogs & derivatives*
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Acetylene / chemistry
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Aldehydes / chemistry
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Animals
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Antineoplastic Agents, Alkylating / chemical synthesis*
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Benzaldehydes / chemistry
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Drug Design
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Drug Screening Assays, Antitumor
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Humans
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Indicators and Reagents
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Indoles / chemistry*
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Kinetics
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Mice
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Pyrroles / chemistry*
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Tumor Cells, Cultured
Substances
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Aldehydes
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Antineoplastic Agents, Alkylating
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Benzaldehydes
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Indicators and Reagents
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Indoles
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Pyrroles
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bis-1-chloromethyl-5-hydroxy-1,2- dihydro-3H-benz(e)indole(seco-CBI)-pyrrole polyamide
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phenylacetylene
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Acetylene