This short review describes the effects of drugs and nonpharmacologic treatments on large artery stiffness in clinical trials. Arterial stiffness is generally accepted as a predictive factor for cardiovascular morbidity and mortality. The drug-induced reduction in arterial stiffness may parallel the reduction in cardiovascular work. This review summarizes the discussion of a task force that worked on the therapeutic aspects during a Consensus Conference on the 'Clinical applications of arterial stiffness," held in Paris on June 17, 2000. The effects of drugs on arterial stiffness are detailed in patients with hypertension, heart failure, and other arterial diseases. Other issues are raised, including the reversibility of arterial changes following pharmacologic treatment, and the possibility for nonpharmacologic treatment to be effective on arterial stiffness. Directions for future therapeutic trials are suggested.