Certain forms of cellular activation lead to immediate early gene (IEGPs) transcription. The biochemical cascade involving IEGPs has been demonstrated to be an important part that cells response to environmental events. The article reviewed the feature of c-Fos expression in vestibular complexes under stimuli. It was considered that c-Fos expression might be a cue parameter in studying the connection of all vestibular complexes, and to reveal the mechanism of motion sickness.