Plasticity of Pax-5(-/-) pre-B I cells

Cells Tissues Organs. 2002;171(1):38-43. doi: 10.1159/000057690.

Abstract

In Pax-5 deficient mice, B cell development is blocked at the pre-B I cell stage. In contrast to their wild type counterparts, Pax-5(-/-) pre-B I cells posses an extraordinary developmental plasticity showing hematopoietic stem cell features such as pluripotency and self renewing capacity. Here we review the in vitro and in vivo evidence of this intriguing phenomenon.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / physiology*
  • Cell Differentiation / physiology*
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Hematopoietic Stem Cells / physiology*
  • Mice
  • Mice, Knockout
  • Models, Biological
  • PAX5 Transcription Factor
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism

Substances

  • DNA-Binding Proteins
  • PAX5 Transcription Factor
  • Pax5 protein, mouse
  • Transcription Factors