Abstract
The first direct catalytic asymmetric alpha-amination of aldehydes is described herein. alpha-Unbranched aldehydes react in this novel proline-catalyzed reaction with dialkyl azodicarboxylates to give alpha-amino aldehydes in excellent yields and enantioselectivities.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aldehydes / chemistry*
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Amination
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Amines / chemical synthesis*
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Catalysis
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Oxazolidinones / chemical synthesis
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Proline / chemistry
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Stereoisomerism
Substances
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Aldehydes
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Amines
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Oxazolidinones
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Proline