Radical scavenging activities of niacin-related compounds

Biosci Biotechnol Biochem. 2002 Mar;66(3):641-5. doi: 10.1271/bbb.66.641.

Abstract

We investigated whether niacin-related compounds had radical-scavenging activity by electron spin resonance methods. Many compounds, but not trigonelline, had radical-scavenging activity against hydroxyl radicals. However, for the nitric oxide radical and 1,1-diphenyl-2-picrylhydrazyl radical, only nicotinic acid hydrazide and isonicotinic acid hydrazide had scavenging activities. These results suggest that the moiety of hydrazide might have an important role in scavenging abilities of various radicals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biphenyl Compounds
  • Electron Spin Resonance Spectroscopy
  • Free Radical Scavengers / chemistry*
  • Free Radicals
  • Hydroxyl Radical / chemistry
  • Niacin / analogs & derivatives*
  • Niacin / chemistry*
  • Nitric Oxide / chemistry
  • Oxidants / chemistry
  • Picrates / chemistry
  • Reactive Oxygen Species

Substances

  • Biphenyl Compounds
  • Free Radical Scavengers
  • Free Radicals
  • Oxidants
  • Picrates
  • Reactive Oxygen Species
  • Niacin
  • Nitric Oxide
  • Hydroxyl Radical
  • 1,1-diphenyl-2-picrylhydrazyl