Preparation and cytotoxic activity of some new rhodomycin derivatives bearing modifications in the sugar moiety

J Antibiot (Tokyo). 2002 Feb;55(2):181-90. doi: 10.7164/antibiotics.55.181.

Abstract

The synthesis and structural determination of a number of new rhodomycin derivatives, modified in the sugar part are described. The cytotoxicity against leukemic L1210 cells of these compounds is reported, along with beta-rhodomycinone and two regioisomers of the above compounds, which were isolated during the synthetic procedure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anthracyclines / pharmacology*
  • Antibiotics, Antineoplastic / chemical synthesis*
  • Antibiotics, Antineoplastic / pharmacology
  • Leukemia L1210 / drug therapy*
  • Molecular Structure
  • Structure-Activity Relationship
  • Tumor Cells, Cultured / drug effects

Substances

  • Anthracyclines
  • Antibiotics, Antineoplastic
  • rhodomycin