Abstract
[structure: see text] Three different approaches were used for the synthesis of dinucleoside methanephosphonamidates [3'-NH-P(O)(CH3)O-5'], starting from dichloromethylphosphine or dichloromethanephosphonate as the phosphorus-containing moiety. 5'-DMT-3'-amino-3'-deoxythymidine and N(4)-benzoyl-5'-DMT-3'-amino-2',3'-dideoxycytidine were used as the aminonucleoside precursors and the respective 3'-protected nucleosides (thymidine or N(4)-benzoyl-2'-deoxycytidine) as the 5'-hydroxyl reagents.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Chromatography, High Pressure Liquid
-
Chromatography, Thin Layer
-
Circular Dichroism
-
DNA / chemistry
-
DNA / drug effects*
-
Dinucleoside Phosphates / chemical synthesis*
-
Dinucleoside Phosphates / chemistry
-
Magnetic Resonance Spectroscopy
-
Organophosphorus Compounds / chemical synthesis*
-
Organophosphorus Compounds / chemistry
-
Spectrometry, Mass, Fast Atom Bombardment
Substances
-
Dinucleoside Phosphates
-
Organophosphorus Compounds
-
DNA