Abstract
A number of new 2',3'-fused oxirane derivatives were synthesized for structure-activity relationship study. Many of these derivatives exhibit high potency against Candida spp. In addition, sordarin manno epoxide derivative 6 presents in vivo therapeutic effect in mice and is considered a promising antifungal lead within this series.
MeSH terms
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry*
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Antifungal Agents / pharmacology
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Candida / drug effects*
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Drug Design
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Epoxy Compounds / chemical synthesis
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Epoxy Compounds / chemistry
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Epoxy Compounds / pharmacology
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Ethylene Oxide / analogs & derivatives*
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Ethylene Oxide / chemical synthesis*
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Ethylene Oxide / chemistry
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Ethylene Oxide / pharmacology
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Indenes
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Conformation
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Structure-Activity Relationship
Substances
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Antifungal Agents
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Epoxy Compounds
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Indenes
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sordarin
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Ethylene Oxide