Abstract
In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemical synthesis*
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Chloroquine / pharmacology
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Cinchona Alkaloids / chemical synthesis*
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Drug Design
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Drug Resistance
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Erythrocytes / parasitology
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Humans
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Conformation
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Plasmodium / drug effects
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Quinolines / chemical synthesis*
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Structure-Activity Relationship
Substances
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Antimalarials
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Cinchona Alkaloids
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Quinolines
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Chloroquine