Abstract
Glucose is an important metabolite and a structural precursor for articular cartilage and its transport has significant consequences for cartilage development and functional integrity. In this study the expression of facilitative glucose transporters (GLUTs) in human chondrocytes was investigated. Results showed that at least three GLUT isoforms (GLUT1, GLUT3 and GLUT9) are expressed by normal chondrocytes. Given the central role of glucose in chondrocyte physiology and metabolism, its regular provision via GLUTs will influence the metabolic activity and survival of chondrocytes in cartilage matrices.
Copyright 2002 Elsevier Science Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cartilage, Articular / cytology
-
Cartilage, Articular / metabolism*
-
Chondrocytes / metabolism*
-
Gene Library
-
Glucose Transport Proteins, Facilitative
-
Glucose Transporter Type 1
-
Glucose Transporter Type 3
-
Humans
-
Molecular Sequence Data
-
Monosaccharide Transport Proteins / biosynthesis*
-
Monosaccharide Transport Proteins / genetics
-
Nerve Tissue Proteins*
-
Protein Isoforms / biosynthesis
-
Protein Isoforms / genetics
Substances
-
Glucose Transport Proteins, Facilitative
-
Glucose Transporter Type 1
-
Glucose Transporter Type 3
-
Monosaccharide Transport Proteins
-
Nerve Tissue Proteins
-
Protein Isoforms
-
SLC2A1 protein, human
-
SLC2A3 protein, human
-
SLC2A9 protein, human
Associated data
-
GENBANK/AF421859
-
GENBANK/AY034633
-
GENBANK/AY034634