Modulation of insulin signaling in human skeletal muscle in response to exercise

Exerc Sport Sci Rev. 2002 Apr;30(2):85-90. doi: 10.1097/00003677-200204000-00008.

Abstract

Exercise is widely recommended for the treatment of obesity, insulin resistance, and type II diabetes mellitus. Recent discoveries in the molecular and cellular regulation of insulin-mediated glucose metabolism in skeletal muscle have provided a deeper understanding of how exercise modulates insulin action.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Diabetes Mellitus, Type 2 / physiopathology
  • Exercise / physiology*
  • Glycogen Synthase / physiology
  • Humans
  • Insulin / physiology*
  • Insulin Resistance / physiology
  • Muscle, Skeletal / metabolism*
  • Phosphatidylinositol 3-Kinases / physiology
  • Signal Transduction / physiology*

Substances

  • Insulin
  • Glycogen Synthase
  • Phosphatidylinositol 3-Kinases