Abstract
Eight new carbocyclic nucleosides were prepared by mounting a purine (compounds 8-10), 8-azapurine (12 and 13) or pyrimidine (15, 16 and 17b) on the amino group of (1S,3R)-3-aminomethyl-2,2,3-trimethylcyclopentylmethanol (6). All the compounds were evaluated as antiviral and antitumor agents in a variety of assay systems. Only compound 8 showed any cytostatic activity against the tumor cell lines examined.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine / analogs & derivatives*
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Adenosine / pharmacology
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Chlorocebus aethiops
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Cyclopentanes / chemical synthesis*
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Cyclopentanes / pharmacology
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HIV-1 / drug effects
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HIV-2 / drug effects
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HeLa Cells
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Humans
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Structure-Activity Relationship
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Uridine / analogs & derivatives*
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Uridine / pharmacology
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Vero Cells
Substances
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Antineoplastic Agents
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Antiviral Agents
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Cyclopentanes
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Adenosine
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Uridine