The molecular and supramolecular structures of four 1,5,6,10b-tetrahydropyrazolo[1,5-c]quinazolines

Acta Crystallogr C. 2002 May;58(Pt 5):o305-10. doi: 10.1107/s0108270102006200. Epub 2002 Apr 30.

Abstract

The supramolecular structures of the title compounds, 2-phenyl-5-p-tolyl-1,5,6,10b-tetrahydropyrazolo[1,5-c]quinazoline, C(23)H(21)N(3), (I), 5-(4-bromophenyl)-2-phenyl-1,5,6,10b-tetrahydropyrazolo[1,5-c]quinazoline, C(22)H(18)BrN(3), (II), 2-(4-chlorophenyl)-5-phenyl-1,5,6,10b-tetrahydropyrazolo[1,5-c]quinazoline, C(22)H(18)ClN(3), (III), and 5-(4-bromophenyl)-2-(4-chlorophenyl)-1,5,6,10b-tetrahydropyrazolo[1,5-c]quinazoline, C(22)H(17)BrClN(3), (IV), are of two general types. Compounds (I), (II) and (III) form base-paired dimers via N-H.N hydrogen bonds, where (I) and (II) are isomorphous, while in (IV), there are no conventional hydrogen bonds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / antagonists & inhibitors
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Crystallography, X-Ray
  • Dimerization
  • Immunosuppressive Agents / chemistry
  • Models, Molecular
  • Molecular Structure
  • Pyrazoles / chemical synthesis
  • Pyrazoles / chemistry*
  • Quinazolines / chemical synthesis
  • Quinazolines / chemistry*

Substances

  • Amino Acids
  • Anti-Inflammatory Agents, Non-Steroidal
  • Immunosuppressive Agents
  • Pyrazoles
  • Quinazolines