Indonesian medicinal plants. XXIV. Stereochemical structure of perseitol x K+ complex isolated from the leaves of Scurrula fusca (Loranthaceae)

Chem Pharm Bull (Tokyo). 2002 Apr;50(4):489-92. doi: 10.1248/cpb.50.489.

Abstract

A complex of perseitol (D-glycero-D-galacto-heptitol) and K+ ions in a molar ratio of 20:1 was isolated from the leaves of Scurrula fusca (Loranthaceae), which has been traditionally used for the treatment of cancer in Sulawesi Island, Indonesia. The stereochemical structure of the complex in H2O solution has been elucidated by use of several kinds of NMR techniques. Furthermore, it has been found that the complex exhibits a potent inhibitory effect on [3H]-leucine incorporation for protein synthesis in Ehrlich ascites tumor cells in mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Carcinoma, Ehrlich Tumor / metabolism
  • Heptoses / chemistry*
  • Heptoses / isolation & purification
  • Heptoses / pharmacology
  • Indonesia
  • Loranthaceae / chemistry*
  • Mice
  • Molecular Conformation
  • Neoplasm Proteins / antagonists & inhibitors
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry*
  • Potassium / chemistry*
  • Potassium / pharmacology
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Heptoses
  • Neoplasm Proteins
  • perseitol
  • Potassium