Abstract
The pharmacokinetics of piperacillin-tazobactam were investigated in eight anuric intensive care patients treated by continuous venovenous hemodialysis (CVVHD). The elimination half-life of piperacillin was 4.3 +/- 1.2 h, and that of tazobactam was 5.6 +/- 1.3 h. The contribution of CVVHD to the overall elimination was relevant (>25%) for both drugs.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Aged
-
Anuria / therapy*
-
Drug Therapy, Combination / pharmacokinetics*
-
Drug Therapy, Combination / therapeutic use
-
Humans
-
Intensive Care Units*
-
Male
-
Penicillanic Acid / analogs & derivatives
-
Penicillanic Acid / pharmacokinetics*
-
Penicillanic Acid / therapeutic use
-
Piperacillin / pharmacokinetics*
-
Piperacillin / therapeutic use
-
Piperacillin, Tazobactam Drug Combination
-
Renal Dialysis / methods*
Substances
-
Piperacillin, Tazobactam Drug Combination
-
Penicillanic Acid
-
Piperacillin