Secondary metabolites from Centaurea deusta with antimicrobial activity

Anastasia Karioti; Helen Skaltsa; Diamanto Lazari; Marina Sokovic; Begoña Garcia; Catherine Harvala

doi:10.1515/znc-2002-1-213

Secondary metabolites from Centaurea deusta with antimicrobial activity

Z Naturforsch C J Biosci. 2002 Jan-Feb;57(1-2):75-80. doi: 10.1515/znc-2002-1-213.

Authors

Anastasia Karioti¹, Helen Skaltsa, Diamanto Lazari, Marina Sokovic, Begoña Garcia, Catherine Harvala

Affiliation

¹ Department of Pharmacognosy, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, Greece.

PMID: 11926547
DOI: 10.1515/znc-2002-1-213

Abstract

The aerial parts of Centaurea deusta Ten. afforded in addition to several known compounds, mainly sesquiterpene lactones, one new eudesmanolide and one new elemane derivative. Structures of the new compounds were elucidated by spectroscopic methods. The in vitro antifungal and antibacterial activities of the isolated compounds was tested, using the microdilution method. All compounds tested showed high antifungal activity.

MeSH terms

Anti-Infective Agents / chemistry*
Anti-Infective Agents / pharmacology
Antifungal Agents / chemistry*
Antifungal Agents / pharmacology
Aspergillus / drug effects
Asteraceae / metabolism*
Lactones / chemistry
Microbial Sensitivity Tests
Molecular Conformation
Molecular Structure
Penicillium / drug effects
Sesquiterpenes / chemistry
Sesquiterpenes / pharmacology

Substances

Anti-Infective Agents
Antifungal Agents
Lactones
Sesquiterpenes