New highly active taxoids from 9 beta-dihydrobaccatin-9,10-acetals

Bioorg Med Chem Lett. 2002 Apr 8;12(7):1083-6. doi: 10.1016/s0960-894x(02)00069-0.

Abstract

To synthesize new highly active taxoids, we designed and synthesized 9 beta-dihydro-9,10-acetal taxoids. In vitro study of these analogues clearly showed them to be more potent than docetaxel.

MeSH terms

  • Acetals / chemical synthesis*
  • Acetals / pharmacology*
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Docetaxel
  • Drug Screening Assays, Antitumor
  • Humans
  • Neoplasms / drug therapy
  • Paclitaxel / analogs & derivatives*
  • Paclitaxel / chemical synthesis*
  • Paclitaxel / pharmacology
  • Structure-Activity Relationship
  • Taxoids*
  • Tumor Cells, Cultured / drug effects*

Substances

  • Acetals
  • Antineoplastic Agents
  • Taxoids
  • Docetaxel
  • Paclitaxel