Cytotoxic constituents of the stem bark of Neolitsea acuminatissima

J Nat Prod. 2002 Mar;65(3):255-8. doi: 10.1021/np010236w.

Abstract

Three new eudesmanolide sesquiterpenes, neolitacumone A-C (1-3), and one new benzylisoquinoline alkaloid, neolitacumonine (5), along with 27 known compounds were isolated from the stem bark of Neolitsea acuminatissima. The structures of compounds 1-3 and 5 were established on the basis of spectral and chemical evidence. Compounds 2, 3, and 20 were selectively inhibitory to Hep 2,2,15 cells with IC50 values in the range 0.24-0.04 microg/mL. Compound 20 was marginally cytotoxic to Hep G2 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Benzoquinones / chemistry
  • Benzoquinones / isolation & purification
  • Benzoquinones / pharmacology
  • Carcinoma, Hepatocellular / chemically induced
  • Drug Screening Assays, Antitumor
  • Hepatitis B virus
  • Humans
  • Inhibitory Concentration 50
  • Isoquinolines / chemistry
  • Isoquinolines / isolation & purification*
  • Lauraceae / chemistry*
  • Molecular Conformation
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Bark / chemistry
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Taiwan
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents, Phytogenic
  • Benzoquinones
  • Isoquinolines
  • Sesquiterpenes
  • neolitacumone A
  • neolitacumone B
  • neolitacumone C
  • neolitacumonine
  • 2,6-dimethoxy-1,4-benzoquinone