From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase

Nat Prod Rep. 2002 Feb;19(1):60-9. doi: 10.1039/b103713g.

Abstract

This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With 92 references this paper covers the literature up to June 2001 and emphasizes the potential implication of the mammalian glucosamine-6P synthase in type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Ammonia / metabolism*
  • Animals
  • Catalysis
  • Crystallography, X-Ray
  • Diabetes Mellitus, Type 2 / enzymology*
  • Escherichia coli / enzymology
  • Fungi / enzymology
  • Glucosamine / analogs & derivatives*
  • Glucosamine / biosynthesis*
  • Glucose / chemistry*
  • Glucose / metabolism*
  • Glucose-6-Phosphate / analogs & derivatives*
  • Glucose-6-Phosphate / biosynthesis*
  • Glutamine / chemistry
  • Glutamine / metabolism
  • Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / chemistry*
  • Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / metabolism*
  • Humans
  • Hydrolysis
  • Mice
  • Molecular Structure
  • Nitrogen / chemistry
  • Nitrogen / metabolism
  • Protein Conformation
  • Rats
  • Structure-Activity Relationship

Substances

  • Glutamine
  • glucosamine 6-phosphate
  • Glucose-6-Phosphate
  • Ammonia
  • Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
  • Glucose
  • Glucosamine
  • Nitrogen