Abstract
Lincomycin biotransformation was conducted by using Streptomyces venezuelae and Streptomyces phaeochromogenes cell-free extracts. Reaction products were isolated and identified by MS and NMR spectroscopy as lincomycin sulfoxide and lincomycin sulfone. Both compounds arise also by chemical oxidation with hydrogen peroxide; this reaction represents a new efficient way for the preparation of lincomycin sulfoxide and lincomycin sulfone and simultaneously excludes the biotransformation of lincomycin using haloperoxidases.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Hydrogen Peroxide / chemistry*
-
Lincomycin / analogs & derivatives*
-
Lincomycin / analysis
-
Lincomycin / chemical synthesis
-
Lincomycin / chemistry*
-
Magnetic Resonance Spectroscopy
-
Mass Spectrometry
-
Molecular Structure
-
Oxidation-Reduction
-
Peroxidases / chemistry
-
Streptomyces
-
Sulfones / analysis
-
Sulfones / chemical synthesis
-
Sulfoxides / analysis
-
Sulfoxides / chemical synthesis
Substances
-
Sulfones
-
Sulfoxides
-
lincomycin sulfone
-
lincomycin sulfoxide
-
Hydrogen Peroxide
-
Lincomycin
-
Peroxidases