Activity of BMS-284756, a novel des-fluoro(6) quinolone, against Staphylococcus aureus, including contributions of mutations to quinolone resistance

Antimicrob Agents Chemother. 2002 Apr;46(4):1119-21. doi: 10.1128/AAC.46.4.1119-1121.2002.

Abstract

The in vitro activity of BMS-284756 against 602 Staphylococcus aureus isolates, including 152 that were both methicillin and ciprofloxacin resistant (MIC > or = 4 microg/ml), was determined. For ciprofloxacin-susceptible and nonsusceptible isolates, the MICs at which 50% of organisms were inhibited were 0.015 and 2 microg/ml and the MICs at which 90% of organisms were inhibited were 0.03 and 4 microg/ml, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Anti-Infective Agents / pharmacology*
  • DNA Gyrase / genetics
  • DNA Topoisomerase IV / antagonists & inhibitors
  • DNA Topoisomerase IV / genetics
  • DNA, Bacterial / drug effects
  • DNA, Bacterial / genetics
  • Drug Resistance, Microbial
  • Fluoroquinolones*
  • Humans
  • Indoles*
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Mutation / genetics*
  • Quinolones*
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics*
  • Topoisomerase II Inhibitors

Substances

  • Anti-Infective Agents
  • DNA, Bacterial
  • Fluoroquinolones
  • Indoles
  • Quinolones
  • Topoisomerase II Inhibitors
  • DNA Topoisomerase IV
  • DNA Gyrase
  • garenoxacin